SREBF2 -Embedded mir33 Links the Nuclear Bile Acid Receptor FXR to Cholesterol and Lipoprotein Metabolism
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منابع مشابه
SREBF2-embedded mir33 links the nuclear bile acid receptor FXR to cholesterol and lipoprotein metabolism.
1 identify a novel regulatory loop of hepatic cholesterol bio-synthesis and export in mice involving the nuclear bile acid receptor FXR/NR1H4. Through transcriptional regulation of the Srebf2 gene and its intronic microRNA mmu-miR33, FXR is now shown to participate in cholesterol homeostasis by post-transcriptional silencing of mir33 targets, including Abca1, a major determinant of hepatic high...
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published under permission of Elsevier provided by Copyright Clearence Center
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2015
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.115.305317